Rat에서 $Na^{+}-K^{+}$ATPase 활성도와 $Na^{+},;K^{+}$ 배설에 미치는 질산 우라늄의 영향
이기호;윤택구;
Effects of Uranyl Nitrate on $Na^{+}-K^{+}$Adenosine Triphosphatase Activity and Excretion of $Na^{+};and;K^{+}$in Rats
Lee, Kee-Ho;Yun, Taik-Koo;
ABSTRACT
In order to evalulate the cause of polyuric acute tubular necrosis, we measured electrolytes, $Na^{+};and;K^{+}$ excreted in urine, and activities of $Na^{+}-K^{+}$adenosine triphosphatase ($Na^{+}-K^{+}$ATPase) Excretion of $Na^{+};and;K^{+}$ significantly increased in 24hr exposure on the uranyl nitrate and then decreased below the normal level after 3 days. The concentration of $Na^{+};and;K^{+}$ in urines of the rats treated uranyl nitrate was less than that of the normal rats. The activities of $Na^{+}-K^{+}$ATPase decreased only in the group treated with high dose group of uranyl nitrate (30mg/kg BW) on the 3rd day but were not changed in the low dose groups(5 mg/kg BW and 15mg/kg BW).