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J Radiat Prot > Volume 8(2); 1983 > Article
Journal of Radiation Protection 1983;8(2):1-0.
S-2-($omega$-aminoalkylamino) ethyl 유도체(誘導體)들의 방사선장해방호효과(放射線障害防護效果)와 독성(毒性)
Radiprotective Effects of S-2-($omega$-aminoalkylamino) ethyl Derivatives and Their Drug Toxicities
Kim, You-Sun;Kim, Suc-Won;
S-2-($omega-aminoalkylamino) ethyl dihydrogen phosphorothioates and S-2-($omega$-aminoalkylamino) ethyl isothiuronium bromides were prepared from easily available starting compounds via convenient synthetic processes. The isothiuronium derivatives showed extreme drug toxicities as compared to that of AET, which seemed to be due to an intramolecular rearrangement of these compounds. The propyl derivative of the phosphorothioate could show better radioprotective effect than those of AET and WR-638, whereas the ethyl derivative of the equivalent drug dose revealed far less protective effect. The correlation between radioprotective effects, drug toxicities, and chemical structures were discussed through infrared spectroscopy.
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