| Home | E-Submission | Sitemap | Contact Us |  
top_img
J Radiat Prot > Volume 8(2); 1983 > Article
Journal of Radiation Protection 1983;8(2):1-0.
S-2-($omega$-aminoalkylamino) ethyl 유도체(誘導體)들의 방사선장해방호효과(放射線障害防護效果)와 독성(毒性)
김유선;김석원;
Radiprotective Effects of S-2-($omega$-aminoalkylamino) ethyl Derivatives and Their Drug Toxicities
Kim, You-Sun;Kim, Suc-Won;
ABSTRACT
S-2-($omega-aminoalkylamino) ethyl dihydrogen phosphorothioates and S-2-($omega$-aminoalkylamino) ethyl isothiuronium bromides were prepared from easily available starting compounds via convenient synthetic processes. The isothiuronium derivatives showed extreme drug toxicities as compared to that of AET, which seemed to be due to an intramolecular rearrangement of these compounds. The propyl derivative of the phosphorothioate could show better radioprotective effect than those of AET and WR-638, whereas the ethyl derivative of the equivalent drug dose revealed far less protective effect. The correlation between radioprotective effects, drug toxicities, and chemical structures were discussed through infrared spectroscopy.
Editorial Office
#319, Hanyang Institute of Technology Bldg., 222 Wangsimni-ro, Seongdong-gu,Seoul, Republic of Korea
Tel: +82-2-2297-9775   Fax: +82-2-2297-9776
Email: jrpr.editorial@gmail.com
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Copyright © by Korean Association for Radiation Protection. Developed in M2PI