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J Radiat Prot > Volume 33(3); 2008 > Article
Journal of Radiation Protection 2008;33(3):99-0.
방사선 방어효과 예측 가능한 면역증강 인삼 다당체의 활성인자
손혁진;심지영;안지연;윤연숙;송지영;
Representative Parameter of Immunostimulatory Ginseng Polysaccharide to Predict Radioprotection
Son, Hyeog-Jin;Shim, Ji-Young;Ahn, Ji-Yeon;Yun, Yeon-Sook;Song, Jie-Young;
ABSTRACT
According to the increase in the use of radiotherapy to cancer patients, many approaches have been tried to develop new agents for the protection of surrounding normal tissues. However, it is still few applied in the clinic as a radioprotector. We aim to find a representative parameter for radioprotection to easily predict the activity of in vivo experiment from the results of in vitro screening. The polysaccharide extracted from Panax ginseng was used in this study because the immunostimulator has been regarded as one of the radioprotective agent category and was already reported having a promising radioprotective activity through the increase of hematopoietic cells and the production of several cytokines. Mitogenic activity, AK cells activity and nitric oxide production were monitored for the in vitro immunological assay, and endogenous colony-forming unit (e-CFU) was measured as in vivo radioprotective parameter. The immunological activity was increased by the galactose contents of ginseng polysaccharide dependently. The result of this study suggests that mitogenic activity of splenocytes demonstrated a good correlation with in vivo radioprotective effect, and may be used as a representative parameter to screen the candidates for radioprotector.
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